#381 ‒ Alzheimer’s disease in women: how hormonal transitions impact the female brain, the role of HRT, genetics, and lifestyle on risk, and emerging diagnostics and therapies | Lisa Mosconi, Ph.D.
The landscape of neurodegenerative research is undergoing a significant paradigm shift as experts begin to unravel the complex relationship between biological sex, hormonal transitions, and cognitive decline. Dr. Lisa Mosconi,…
Peter Attia AMA 80 Explores Critical Benchmarks for Longevity and Metabolic Health Optimization
The latest installment of the "Ask Me Anything" (AMA) series from Dr. Peter Attia, a prominent figure in the field of longevity medicine, has provided a comprehensive synthesis of current…
Dr. Peter Attia Explores the Frontiers of Longevity Science and Personalized Medicine in Comprehensive AMA Episode 81
The landscape of modern longevity science is shifting from a reactive model of treating disease to a proactive framework focused on extending both lifespan and healthspan. In the latest "Ask…
The Relationship Between Circulating Cholesterol Levels and Long-Term Cognitive Health
The human brain is an extraordinary biological anomaly, serving as the most cholesterol-dense organ in the body. While the brain accounts for a mere 2% of total body mass, it…
The Future of Multi-Cancer Early Detection and the Nuanced Reality of the NHS-Galleri Trial Results
The landscape of oncology and preventative medicine faced a significant moment of volatility following the release of preliminary data from the NHS-Galleri trial, a massive study evaluating the efficacy of…
The Evolving Landscape of Cardiovascular Prevention and the Metabolic Impact of Statin Therapy on Insulin Sensitivity and GLP-1 Secretion
Cardiovascular disease remains the leading cause of mortality globally, accounting for an estimated 17.9 million deaths annually. For decades, statins—formally known as HMG-CoA reductase inhibitors—have served as the primary pharmacological…
The MET-PREVENT Trial and the Future of Metformin in Geroprotection: Analyzing the Impact on Sarcopenia and Physical Frailty in the Elderly
The medical community has long scrutinized metformin, a biguanide primarily indicated for Type 2 diabetes mellitus, for its potential secondary applications in the field of longevity and geroprotection. While its…
The Therapeutic Evolution of GLP-1 Receptor Agonists from Glycemic Control to Neuroprotective Prophylaxis against Dementia and Chronic Disease
The pharmaceutical landscape is currently witnessing a paradigm shift as a class of drugs originally designed for glycemic control in type 2 diabetes (T2D) emerges as a potential multi-purpose therapeutic…
Navigating the Shift in Alcohol Consumption Standards and the Impact of Moderate Drinking on Global Healthspan
The global medical community is currently undergoing a paradigm shift regarding the consumption of alcohol, moving away from a decade-long acceptance of moderate drinking toward a more cautious, risk-averse stance.…
Physiological Constraints on Concurrent Muscle Hypertrophy and Oxidative Capacity in Human and Murine Models
The pursuit of peak physical performance has long been categorized into two distinct domains: the quest for maximal muscular hypertrophy and strength, typical of bodybuilders and powerlifters, and the pursuit…
















